Opportunity Information: Apply for RFA DK 15 019
The grant opportunity titled "Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3)" (Funding Opportunity Number RFA-DK-15-019) is a discretionary NIH research grant designed to support studies focused specifically on complications of type 1 diabetes. The central goal is to encourage investigators to take advantage of existing resources from prior or ongoing type 1 diabetes clinical studies, particularly by using already-enrolled human subjects and/or previously collected biospecimens. In practical terms, the program is aimed at accelerating new discoveries about why complications happen, how they progress, and what factors might predict or influence outcomes, by leveraging the value of well-characterized clinical study cohorts and sample collections rather than starting entirely new cohorts from scratch.
The opportunity sits in NIH's health-related funding portfolio (CFDA 93.847) and is categorized under Food and Nutrition, Health. It uses the grant funding instrument and is labeled with the DP3 mechanism, indicating a targeted program type intended to drive a particular research aim. The FOA was created on October 8, 2015, with an original closing date of March 3, 2016. The posted award ceiling is $1,000,000, which signals that projects were expected to be substantial in scope, potentially involving complex analyses of clinical data, deep phenotyping of complications, advanced laboratory assays on stored biosamples, or follow-on clinical evaluations of participants from legacy studies.
A defining feature of this announcement is the emphasis on "using subjects and/or samples from clinical studies on type 1 diabetes." That phrasing points toward research that is anchored in established clinical-study infrastructures: cohorts with known histories, standardized data collection, and existing consent frameworks, as well as biorepositories containing blood, urine, tissue, DNA, or other materials collected under rigorous protocols. By focusing on these already-developed assets, applicants would be expected to propose efficient, well-justified studies that extract new scientific value from prior investments in type 1 diabetes clinical research, especially around microvascular and macrovascular complications and other long-term outcomes that can be difficult and expensive to study prospectively.
Eligibility is broad and intentionally inclusive. Standard eligible applicants include a wide range of U.S. government entities (state, county, city/township, and special district governments), independent school districts, public housing authorities and Indian housing authorities, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized tribal governments. Academic eligibility includes public and state-controlled institutions of higher education as well as private institutions of higher education. The FOA also allows participation by nonprofit organizations both with and without IRS 501(c)(3) status (as long as they are not institutions of higher education in those categories), and it explicitly includes for-profit organizations (other than small businesses) and small businesses. In addition, the announcement highlights other eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, tribal governments other than federally recognized ones, and even non-U.S. entities (foreign organizations). Taken together, that scope suggests NIH wanted to draw proposals from many kinds of institutions, including those serving underserved or underrepresented communities, and also to allow international expertise where it could strengthen the science.
In summary, this FOA is best understood as an NIH-funded push to deepen understanding of type 1 diabetes complications by reusing and reanalyzing high-value human subjects and biospecimen resources from existing clinical studies. It supports applicants across academia, government, nonprofit, and industry, including domestic and foreign organizations, with a relatively high maximum award level that could accommodate multidisciplinary projects. The intent is to generate new insights efficiently by building on established cohorts and sample repositories, rather than recreating them, ultimately helping clarify mechanisms, risk factors, biomarkers, and trajectories of complications in type 1 diabetes.Apply for RFA DK 15 019
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2015-10-08.
- Applicants must submit their applications by 2016-03-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DK-15-019.
What type of grant is this?
This is a discretionary NIH research grant that uses the NIH grant funding instrument and is offered under the DP3 mechanism (a targeted program type intended to drive a specific research aim).
What is the main purpose of this FOA?
The central purpose is to support research focused specifically on complications of type 1 diabetes by encouraging investigators to use existing resources from prior or ongoing type 1 diabetes clinical studies, including already-enrolled human subjects and/or previously collected biospecimens.
What scientific topic does the FOA focus on?
The focus is on complications of type 1 diabetes, including long-term outcomes that may involve microvascular and macrovascular complications and other difficult-to-study complication trajectories.
What is the key research approach encouraged by this FOA?
The defining feature is reuse of established clinical study resources: leveraging well-characterized cohorts and existing biorepository samples rather than starting entirely new cohorts from scratch.
What kinds of resources are applicants expected to use?
Applicants are expected to take advantage of assets from prior or ongoing type 1 diabetes clinical studies, particularly (1) already-enrolled human subjects and/or (2) previously collected biospecimens stored in biorepositories.
Does the FOA require using human subjects, biospecimens, or both?
The FOA emphasizes using subjects and/or samples from clinical studies on type 1 diabetes, meaning proposals may be based on already-enrolled participants, previously collected biospecimens, or a combination of both.
Why does the FOA emphasize existing cohorts and biospecimens?
The intent is to accelerate discovery by building on prior investments in type 1 diabetes clinical research, using cohorts with known histories and standardized data collection and samples collected under rigorous protocols, which can make research on complications more efficient and well-justified.
What kinds of studies might fit within the scope described?
Based on the scope described, projects could include complex analyses of clinical data, deep phenotyping of complications, advanced laboratory assays on stored biosamples, or follow-on clinical evaluations of participants from legacy studies, all aimed at understanding why complications occur, how they progress, and what predicts outcomes.
What types of biospecimens are referenced as examples?
The FOA references biorepositories that may include blood, urine, tissue, DNA, or other materials collected under rigorous protocols.
What kinds of outcomes or insights is the program trying to generate?
The program aims to generate new insights into mechanisms, risk factors, biomarkers, and trajectories of type 1 diabetes complications, including factors that may predict or influence outcomes.
What is the CFDA number and category for this opportunity?
This opportunity is listed under CFDA 93.847 and categorized under Food and Nutrition, Health.
When was the FOA created?
The FOA was created on October 8, 2015.
What was the original closing date?
The original closing date was March 3, 2016.
What is the maximum (ceiling) award amount?
The posted award ceiling is $1,000,000.
What does the $1,000,000 award ceiling suggest about project scope?
The ceiling suggests projects were expected to be substantial in scope, potentially supporting multidisciplinary research and analyses that can involve complex clinical datasets, advanced assays, and/or follow-on evaluations within established cohorts.
Who is eligible to apply?
Eligibility is broad and includes many organization types across government, academia, nonprofit, and industry, as well as foreign (non-U.S.) entities.
Which U.S. government entities are eligible applicants?
Eligible U.S. government applicants include state governments, county governments, city or township governments, special district governments, independent school districts, public housing authorities, and Indian housing authorities.
Are federally recognized Native American tribal governments eligible?
Yes. Federally recognized Native American tribal governments are included as eligible applicants.
Are Native American tribal organizations that are not federally recognized eligible?
Yes. Native American tribal organizations (other than federally recognized tribal governments) are explicitly included.
Are colleges and universities eligible?
Yes. Eligible academic applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are eligible both with and without IRS 501(c)(3) status (as long as they are not institutions of higher education in those categories).
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are explicitly included, and small businesses are also eligible.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations among eligible applicant types.
Are minority-serving institutions highlighted as eligible?
Yes. The FOA highlights multiple minority-serving institution categories as eligible, including HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are listed among eligible applicant types.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are included in the eligible applicant types.
Are regional organizations eligible?
Yes. Regional organizations are included among eligible applicant types.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA indicates that non-U.S. entities (foreign organizations) are eligible.
What is the overall intent of funding this program?
The intent is to deepen understanding of type 1 diabetes complications efficiently by reusing and reanalyzing high-value human subject and biospecimen resources from existing clinical studies, rather than recreating cohorts, thereby accelerating discovery related to complication mechanisms and predictors.
Browse more opportunities from the same category: Food and Nutrition, Health
Next opportunity: Polycystic Kidney Disease Core Centers (U54 Clinical Trial Not Allowed)
Previous opportunity: Comprehensive HIV Prevention, Care and Treatment for the National Defense Force of Ethiopia (NDFE) under the President’s Emergency Plan for AIDS Relief (PEPFAR)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DK 15 019
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DK 15 019) also looked into and applied for these:
| Funding Opportunity |
|---|
| Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional) Apply for RFA DK 25 024 Funding Number: RFA DK 25 024 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Central Coordinating Site for the Polycystic Kidney Disease Research Core Centers (U24 Clinical Trial Not Allowed) Apply for RFA DK 25 015 Funding Number: RFA DK 25 015 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Polycystic Kidney Disease Core Centers (U54 Clinical Trial Not Allowed) Apply for RFA DK 25 016 Funding Number: RFA DK 25 016 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Single Source for the Continuation of the Type 1 Diabetes in Acute Pancreatitis Consortium - Data Coordinating Center (T1DAPC-DCC) (U01 Clinical Trial Optional) Apply for RFA DK 25 018 Funding Number: RFA DK 25 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $800,000 |
| Limited Competition for the Continuation of Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical Centers (T1DAPC-CCs) (U01 Clinical Trial Optional) Apply for RFA DK 25 017 Funding Number: RFA DK 25 017 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Research Resource for Human Organs and Tissues (U42 Clinical Trial Not Allowed) Apply for PAR 24 258 Funding Number: PAR 24 258 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Urology Centers Program Interactions Core (U24 Clinical Trial Not Allowed) Apply for RFA DK 26 002 Funding Number: RFA DK 26 002 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Cellular Models of HIV Pathogenesis within NIDDK Mission Areas (R01 Clinical Trial Not Allowed) Apply for RFA DK 25 021 Funding Number: RFA DK 25 021 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Precision Medicine for Type 1 Diabetic Nephropathy (U01 Clinical Trial Not Allowed) Apply for RFA DK 25 022 Funding Number: RFA DK 25 022 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $400,000 |
| Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed) Apply for PAS 25 205 Funding Number: PAS 25 205 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Centers for Diabetes Translation Research (P30 Clinical Trial Optional) Apply for RFA DK 26 001 Funding Number: RFA DK 26 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional) Apply for PAR 25 277 Funding Number: PAR 25 277 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Continuation of the NIDDK Hematology Central Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA DK 25 023 Funding Number: RFA DK 25 023 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Catalyst Award (DP1 Clinical Trial Not Allowed) Apply for RFA DK 26 006 Funding Number: RFA DK 26 006 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) Apply for PA 25 147 Funding Number: PA 25 147 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) Apply for PAR 25 089 Funding Number: PAR 25 089 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional) Apply for PAS 25 073 Funding Number: PAS 25 073 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Small Grants for New Investigators to Broaden Participation in Health-Related Research (R21 Clinical Trial Optional) Apply for PAR 25 097 Funding Number: PAR 25 097 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $125,000 |
| Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed) Apply for PAR 25 068 Funding Number: PAR 25 068 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required) Apply for PAS 25 102 Funding Number: PAS 25 102 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DK 15 019", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.