Opportunity Information: Apply for RFA PM 23 002
The National Institutes of Health (NIH), through the All of Us Research Program in the NIH Office of the Director, is offering a small-grants opportunity to encourage more researchers to use the All of Us Researcher Workbench and to generate studies that align with high-priority mission areas across NIH Institutes, Centers, and Offices (ICOs). The focus of this particular funding announcement is on projects that analyze data already available in the All of Us Research Program using established, standard analytic methods. It is explicitly labeled "Clinical Trial Not Allowed," meaning applicants must propose research that does not involve conducting a clinical trial.
This funding opportunity is part of a paired approach. One companion announcement supports straightforward data analysis with standard methods under the R03 mechanism (this opportunity), while the other companion announcement uses the R21 mechanism to support the development of new methods, models, or tools and then applying those innovations to Workbench data. A key distinction is that tool-building and method development belong under the R21 companion, whereas this R03 is meant to support research questions that can be addressed now with conventional approaches using the currently accessible All of Us dataset in the Workbench environment.
The grant mechanism is an NIH R03 (Small Grant), which is typically used to support smaller, tightly scoped projects, feasibility work, secondary data analyses, or other limited efforts that can produce useful results relatively quickly. Here, the emphasis is on enabling investigators to conduct analyses within the Workbench and contribute findings relevant to NIH priority areas, rather than building brand-new computational infrastructure. The announcement also notes that, in the companion R21 pathway, newly developed tools are expected to be made broadly available to the scientific community; by contrast, this R03 pathway is centered on using existing tools and standard methods to produce research outputs.
Eligibility is broad across many U.S.-based organization types, reflecting NIH's intent to draw participation from a wide range of sectors. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The announcement also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, certain eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, it clearly excludes non-domestic applicants: foreign institutions and foreign organizations are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as NIH defines them in its Grants Policy Statement) are not allowed.
The program is listed as a discretionary grant opportunity under NIH, with a funding opportunity number of RFA-PM-23-002 and title "Small Grants to Enhance the Use of the All of Us Research Programs Data (R03 Clinical Trial Not Allowed)." The original closing date shown is March 1, 2023, and the opportunity is associated with multiple CFDA (Assistance Listing) numbers spanning many NIH institutes and program areas, signaling broad relevance across biomedical and health research domains. While the provided source text does not specify an award ceiling or number of expected awards, the central purpose is clear: expand and strengthen the community of researchers using All of Us data by funding focused, standard-method analyses that can advance NIH mission priorities without conducting clinical trials.Apply for RFA PM 23 002
- The National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Small Grants to Enhance the Use of the All of Us Research Programs Data (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.310, 93.313, 93.350, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2022-12-23.
- Applicants must submit their applications by 2023-03-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this NIH funding opportunity?
This is a National Institutes of Health (NIH) small-grants opportunity offered through the All of Us Research Program in the NIH Office of the Director. It is intended to encourage more researchers to use the All of Us Researcher Workbench and to generate studies aligned with high-priority mission areas across NIH Institutes, Centers, and Offices (ICOs).
What is the official funding opportunity number and title?
The funding opportunity number is RFA-PM-23-002. The title is "Small Grants to Enhance the Use of the All of Us Research Programs Data (R03 Clinical Trial Not Allowed)".
What grant mechanism does this opportunity use?
This opportunity uses the NIH R03 (Small Grant) mechanism, which is commonly used for smaller, tightly scoped projects, feasibility efforts, and secondary data analyses that can produce useful results relatively quickly.
What is the main goal of this R03 announcement?
The main goal is to expand and strengthen the community of researchers using All of Us data by supporting focused projects that analyze data already available in the All of Us Research Program through the Researcher Workbench, using established and standard analytic methods.
What kind of research is this opportunity looking for?
The focus is on projects that can be done now using the currently accessible All of Us dataset in the Researcher Workbench, applying conventional, established analytic approaches to answer research questions that align with NIH priority areas.
Does the project have to use the All of Us Researcher Workbench?
Yes. The purpose of the opportunity is to encourage researchers to use the All of Us Researcher Workbench and to generate studies based on data available within that environment.
Are clinical trials allowed under this announcement?
No. The announcement is explicitly labeled "Clinical Trial Not Allowed". Proposed research must not involve conducting a clinical trial.
Can applicants propose to develop new analytic methods, models, or software tools under this R03?
This R03 is described as supporting research that uses established, standard analytic methods on existing Workbench data. Tool-building and new method development are identified as belonging under the companion R21 announcement rather than this R03.
How is this R03 different from the companion R21 announcement?
The NIH describes a paired approach:
- R03 (this opportunity): straightforward analysis using established, standard analytic methods applied to currently available All of Us data in the Workbench.
- R21 (companion): development of new methods, models, or tools, followed by applying those innovations to Workbench data.
Is building new computational infrastructure a focus of this R03?
No. The emphasis is on enabling investigators to conduct analyses within the Workbench using existing tools and standard methods, rather than creating brand-new computational infrastructure.
What is meant by aligning with "high-priority mission areas" across NIH?
The announcement emphasizes that projects should generate studies relevant to high-priority mission areas across NIH Institutes, Centers, and Offices (ICOs). In other words, the work should be positioned to contribute findings that support NIH-wide biomedical and health research priorities.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organization types, including:
- State, county, city/township, and special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized tribal governments
- Tribal organizations that are not federally recognized
- Public housing authorities/Indian housing authorities
- Nonprofits with or without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
- Other eligible entities
Are minority-serving institutions and community-based organizations included in eligible applicant categories?
Yes. The announcement highlights additional eligible applicant categories such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Faith-based or community-based organizations
- Certain eligible federal agencies
- Regional organizations
- U.S. territories or possessions
Are foreign organizations or non-U.S. components allowed to apply?
No. The announcement clearly excludes non-domestic applicants. Foreign institutions and foreign organizations are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed (as NIH defines them in its Grants Policy Statement).
Is this opportunity a discretionary grant?
Yes. It is listed as a discretionary grant opportunity under NIH.
What is the closing date listed for this opportunity?
The original closing date shown is March 1, 2023.
Does the provided information specify the maximum award amount or number of awards?
No. The provided source text does not specify an award ceiling or the expected number of awards.
What does it mean that multiple CFDA (Assistance Listing) numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA (Assistance Listing) numbers spanning many NIH institutes and program areas. Based on the information provided, this signals broad relevance across biomedical and health research domains and alignment with priorities across multiple NIH components.
What outputs or outcomes is NIH trying to encourage through this R03?
Based on the description, NIH is aiming to fund focused analyses that produce research findings and outputs relevant to NIH mission priorities, while expanding the number of investigators actively using the All of Us Researcher Workbench and its currently available data resources.
If my idea centers on creating a new tool that should be broadly shared, is this R03 the right fit?
Not according to the way this paired approach is described. The companion R21 pathway is presented as the place for new methods/models/tools, with an expectation that newly developed tools are made broadly available to the scientific community. This R03 is framed around using existing tools and standard methods to answer research questions using current Workbench data.
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